![]() ![]() CREB1 and VIP are mainly enriched in pathways of energy metabolism, ion channels, and myocardial contraction. hsa-miR-662 was identified by database integration analysis to regulate the transcription factor CREB1, a potential transcriptional regulator in VIP. In this study, eight DEmRNAs and four miRNAs were screened. ![]() Subsequently, the hsa-miR-662-CREB1-VIP axis was obtained, and the role of CREB1 and VIP in the development of AF after MI was further revealed by single-cell analysis and prediction model construction. ![]() We downloaded three datasets from the GEO database, and after performing differential and crosstabulation analyses, we screened out differentially expressed (DE) miRNAs and DEmRNAs coexpressed in AF and MI and performed DEmiRNA–DEmRNA pairing prediction from which, we constructed a regulatory network. This study was aimed at investigating the regulatory network that affects neuropeptide expression through transcription factor modulation. Neuropeptide levels are closely associated with the development and maintenance of atrial fibrillation (AF) after myocardial infarction (MI). ![]()
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